منابع مشابه
In vitro activity of fosfomycin-gentamicin, fosfomycin-ceftazidime, fosfomycin-imipenem and ceftazidime-gentamicin combinations against ceftazidime-resistant Pseudomonas aeruginosa.
The effects of antimicrobial combinations against ceftazidime-resistant Pseudomonas aeruginosa strains isolated from hospitalized patients were investigated. Using the checkerboard titration method, combination of fosfomycin-gentamicin, fosfomycin-ceftazidime, fosfomycin-imipenem and ceftazidime-gentamicin was synergistic against 4, 11, 38 and 39% of 22, 18, 29 and 18 strains tested respectivel...
متن کاملTransposon Encoding Fosfomycin Resistance
The determinant of resistance to fosfomycin of the Serratia marcescens plasmid pOU900 was transposed into the plasmid ColEl and into the plasmid RP4 in the absence of the RecA function of the host. In each case, the acquisition of fosfomycin resistance was correlated with the presence of a discrete piece of DNA, uniform in size and in restriction pattern. This new, 7.5-megadalton transposable e...
متن کاملFosfomycin monophosphate and fosfomycin diphosphate, two inactivated fosfomycin derivatives formed by gene products of fomA and fomB from a fosfomycin producing organism Streptomyces wedmorensis.
Fig. 1. Structures of FMand FMderivatives inactivated by gene products offomA andfomB. analysis revealed the presence of six open reading frames with unknownfunctions in the sequenced fragment, in addition to the four genes necessary to FMbiosynthesis. So far studied, most antibiotic-producing Streptomyces possessed resistance genes and regulatory genes in their antibiotic production gene clust...
متن کاملFosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.
Escherichia coli cells carrying fosfomycin resistance plasmids were able to take up fosfomycin from the medium to the same extent as plasmid-free bacteria. The antibiotic entered the plasmid-harboring cells by means of the glpT and uhp transport systems, as is the case with susceptible bacteria. Active fosfomycin could be detected in soluble extracts of cells which had previously been incubated...
متن کاملSynergy between fosfomycin and arenaemycin.
Synergy was evident in zones of inhibition between neighboring filter discs containing fosfomycin and an unidentified fermentation broth placed on the surface of agar growth medium seeded with Bacillus megaterium (S. Mochales ; personal communication). The antibiotic was isolated and identified as arenaemycin (T. Miller and K. Wilson; personal communication). We report in this communication tha...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2016
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.00068-15